Schisandrin B protects against angiotensin II-induced endotheliocyte deficits by targeting Keap1 and activating Nrf2 pathway
نویسندگان
چکیده
منابع مشابه
Gastrodin protects against LPS-induced acute lung injury by activating Nrf2 signaling pathway
Gastrodin (GAS), a phenolic glucoside derived from Gastrodiaelata Blume, has been reported to have anti-inflammatory effect. The aim of this study was to investigate the effects of GAS on LPS-induced acute lung injury in mice. ALI was induced by the intranasal administration of LPS and GAS was given 1 h or 12 h after LPS treatment. The results indicated that GAS treatment markedly attenuated th...
متن کاملPaeonia lactiflora Pall. protects against ANIT-induced cholestasis by activating Nrf2 via PI3K/Akt signaling pathway
BACKGROUND Paeonia lactiflora Pall. (PLP), a traditional Chinese herbal medicine, has been used for hepatic disease treatment over thousands of years. In our previous study, PLP was shown to demonstrate therapeutic effect on hepatitis with severe cholestasis. The aim of this study was to evaluate the antioxidative effect of PLP on alpha-naphthylisothiocyanate (ANIT)-induced cholestasis by activ...
متن کاملMicroRNA-7 activates Nrf2 pathway by targeting Keap1 expression.
Nuclear factor E2-related factor 2 (Nrf2) is a key transcription factor that regulates the expression of a number of antioxidant and detoxifying genes that provide cellular protection against various stressors including reactive oxygen species (ROS). Nrf2 activity is tightly regulated by a cytoplasmic inhibitory protein called Kelch-like ECH-associated protein 1 (Keap1). The mechanism that cont...
متن کاملXylaria nigripes protects mice against cerebral ischemic injury by activating Nrf2/HO-1 pathway
Xylaria nigripes (XN) is a fungus used in traditional Chinese medicine and its extracts have been shown anti-oxidant and anti-inflammatory activities. This study was to determine the protective effect of XN against ischemic stroke induced neurotoxicity. Ischemic stroke mouse model was established by middle cerebral artery occlusion (MCAO). XN and 40 mol/Kg SnPP were injected intraperitoneally o...
متن کاملGrape seed proanthocyanidin extract protects the retina against early diabetic injury by activating the Nrf2 pathway
The present study aimed to investigate whether grape seed proanthocyanidin extract (GSPE) has a protective effect on diabetic retinal function. A total of 30 Wistar rats were randomly divided into three equal groups, including the control, diabetic and GSPE-treated diabetic groups. Retinal tissue was harvested and subsequently stained with hematoxylin and eosin. Superoxide dismutase (SOD), glut...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Drug Design, Development and Therapy
سال: 2018
ISSN: 1177-8881
DOI: 10.2147/dddt.s184245